Yanbing ZU

Principal Research Scientist

Tel: +65 6319 4916

Email: ybzu@imre.a-star.edu.sg

Principal Research Scientist, NanoBio Lab, Singapore, 2018‐present

Principal Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, 2014‐2018

Senior Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, 2008‐2014

Research Assistant Professor, The University of Hong Kong, 2002‐2007

Post‐doctoral Fellow, MRC‐Dunn Human Nutrition Unit, Cambridge, UK, 2001‐2002

Post‐doctoral Fellow, The University of Texas at Austin, Austin, TX, USA, 1998‐2000

Ph.D. in Chemistry, Wuhan University, China, 1995

M.Sc. in Chemistry, Wuhan University, China, 1992

B.Sc. in Chemistry, Fudan University, China, 1989


  1. Y. Zu, M. H. Tan, E. C. Ren, J. Y. Ying, “Facile and Phase‐Defined Determination of HLA Alleles with Morpholino‐Functionalized Nanoparticle Probes,” Nanomedicine, 13[2] (2017) 611‐618

  2. Y. Zu, M.‐H. Tan, B. Chowbay, S. C. Lee, H. Yap, M. T. M. Lee, L.‐S. Lu, C.‐P. Chang, J. Y. Ying, “Nanoprobe‐Based Genetic Testing,” Nano Today, 9[2] (2014) 166‐171

  3. P. Y. Hon, K. S. Chan, M. T. Holden, S. R. Harris, T. Y. Tan, Y.‐B. Zu, P. Krishnan, L. L. Oon, T. H. Koh, L. Y. Hsu, “ACME in Singaporean ST239‐MRSA‐III Isolates ‐ Implications for PCR‐Based Screening Tests,” Antimicrobial Agents and Chemotherapy, 57 (2013) 1563‐1564

  4. Y. Zu, A. L. Ting, G. Yi, Z. Gao, “Sequence‐Selective Recognition of Nucleic Acids under Extremely Low Salt Conditions Using Nanoparticle Probes,” Analytical Chemistry, 83 (2011) 4090‐4094

  5. X. J. Chen, Y. B. Zu, H. Xie, A. M. Kemas, Z. Q. Gao, “Coordination of Mercury(II) to Gold Nanoparticle Associated Nitrotriazole Towards Sensitive Colorimetric Detection of Mercuric Ion with Tunable Dynamic Range,” Analyst, 136 (2011) 1690‐1696

  6. Y. Zu, A. L. Ting, Z. Gao, “Visualizing Low‐Level Point Mutations: Enzyme‐Like Selectivity Offered by Nanoparticle Probes,” Small, 7 (2011) 306‐310

  7. Z. F. Chen and Y. Zu, “Electrogenerated Chemiluminescence of the Tris(2,2'‐bipyridine)ruthenium(II)/Tertiary Amine Systems: Effects of Electrode Surface Hydrophobicity on the Low‐Oxidation‐Potential Emission,” J. Phys. Chem. C, 113 (2009) 21877‐21882

  8. Y. Zu, “Molecular and Nanoparticle Postcolumn Reagents for Assay of Low‐Molecular‐Mass Biothiols using High‐Performance Liquid Chromatograph,” (invited review) J. Chromatogr. B, 877 (2009) 3358‐3365

  9. Z. F. Chen, K. M.‐C. Wong, V. K.‐M. Au, Y. Zu, V. W. W. Yam, “Electrogenerated Chemiluminescence of a Bis‐cyclometalated Alkynylgold(III) Complex with Irreversible Oxidation Using Tri‐n‐propylamine as Co‐reactant,” Chem. Commun., (2009) 791‐793

  10. Y. B. Zu and Z. Q. Gao, “Facile and Controllable Loading of Single‐Stranded DNA on Gold Nanoparticles,” Analytical Chemistry, 81 (2009) 8523‐8528

  11. Z. F. Chen and Y. Zu, “Electrogenerated Chemiluminescence of the Tris(2,2'‐bipyridine)ruthenium(II)/Tri‐n‐propylamine (TPrA) System: Crucial Role of the Long Lifetime of TPrAo+ Cation Radicals Suggested by Electrode Surface Effects,” J. Phys. Chem. C, 112 (2008) 16663‐16667

  12. Z. F. Chen and Y. Zu, “Electrochemical Recognition of Single‐Methylene Difference between Cysteine and Homocysteine,” J. Electroanal. Chem., 624 (2008) 9‐13

  13. M. J. Li, Z. F. Chen, V. W. W. Yam, Y. Zu, “Multifunctional Ruthenium(II) Polypyridine Complex‐Based Core‐Shell Magnetic Silica Nanocomposites: Magnetism, Luminescence, and Electrochemiluminescence,” ACS Nano, 2 (2008) 905‐912

  14. M. J. Li, Z. F. Chen, N. Y. Zhu, V. W. W. Yam, Y. Zu, “Electrochemiluminescence of Ruthenium(II) Complexes Functionalized with Crown Ether Pendants and Effects of Cation‐Binding,” Inorg. Chem., 47 (2008) 1218‐1223

  15. Z. F. Chen and Y. Zu, “Selective Detection of Uric Acid in the Presence of Ascorbic Acid Based on Electrochemiluminescence Quenching,” J. Electroanal. Chem., 612 (2008) 151‐155

  16. Z. F. Chen and Y. Zu, “Gold Nanoparticle‐Modified ITO Electrode for Electrogenerated Chemiluminescence: Well‐Preserved Transparency and Highly Enhanced Activity,” Langmuir, 23 (2007) 11387‐11390

  17. Z. F. Chen, H. Z. Zheng, C. Lu, Y. Zu, “Oxidation of L‐Cysteine at a Fluorosurfactant‐Modified Gold Electrode: Lower Overpotential and Higher Selectivity,” Langmuir, 23 (2007) 10816‐10822

  18. C. Lu, Y. Zu, V. W. W. Yam, “Nonionic Surfactant‐Capped Gold Nanoparticles as Postcolumn Reagents for High‐Performance Liquid Chromatography Assay of Low‐Molecularmass Biothiols,” J. Chromatogr. A, 1163 (2007) 328‐332

  19. C. Lu and Y. Zu, “Specific Detection of Cysteine and Homocysteine: Recognizing One‐Methylene Difference Using Fluorosurfactant‐Capped Gold Nanoparticles,” Chem. Commun., 37 (2007) 3871‐ 3873

  20. X.‐H. N. Xu and Y. Zu, “Electrochemiluminescence Detection in Bioanalysis,” In New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis; X.‐H. N. Xu, Ed.; Wiley: New York; (2007) 235‐267

  21. Z. F. Chen and Y. Zu, “Simultaneous Detection of Ascorbic Acid and Uric Acid Using a Fluorosurfactant‐modified Platinum Electrode,” J. Electroanal. Chem., 603 (2007) 281‐286

  22. C. Lu, Y. Zu, V. W. W. Yam, “Specific Postcolumn Detection Method for HPLC Assay of Homocysteine Based on Aggregation of Fluorosurfactant‐Capped Gold Nanoparticles,” Anal. Chem., 79 (2007) 666‐672

  23. H. Zheng and Y. Zu, “Highly Efficient Quenching of Coreactant Electrogenerated Chemiluminescence by Phenolic Compounds,” J. Phys. Chem. B, 109 (2005) 16047‐16051

  24. H. Zheng and Y. Zu, “Emission of Tris(2,2'‐bipyridine)ruthenium(II) by Coreactant Electrogenerated Chemiluminescence: From O2‐Insensitive to Highly O2‐Sensitive,” J. Phys. Chem. B, 109 (2005) 12049‐12053

  25. Y. Zu and F. Li, “Characterization of the Low‐Oxidation‐Potential Electrogenerated Chemiluminescence of Tris(2,2'‐bipyridine)ruthenium(II) with Tri‐n‐propylamine as Coreactant,” Anal. Chim. Acta, 550 (2005) 47‐52

  26. F. Li and Y. Zu, “Effect of Nonionic Fluorosurfactant on the Electrogenerated Chemiluminescence of the Tris(2,2'-bipyridine)ruthenium(II)/tri‐n‐propylamine System: Lower Oxidation Potential and Higher Emission Intensity,” Anal. Chem., 76 (2004) 1768‐1772

  27. Y. Zu, M. M.‐J. Couture, D. R. J. Kolling, A. R. Crofts, L. D. Eltis, J. A. Fee, J. Hirst, “Reduction Potentials of Rieske Clusters: Importance of the Coupling between Oxidation State and Histidine Protonation State,” Biochemistry (US), 42 (2003) 12400‐12408

  28. Y. Zu, R. J. Shannon, J. Hirst, “Reversible, Electrochemical Interconversion of NADH and NAD+ by the Catalytic Subcomplex of Mitochondrial NADH:Ubiquinone Oxidoreduxtase (Complex I),” J. Am. Chem. Soc., 125 (2003) 6020‐6021

  29. Y. Zu, J. A. Fee, J. Hirst, “Breaking and Re‐Forming of Disulfide Bond at the High‐Potential, Respiratory‐Type Rieske [2Fe‐2S] Center of Thermus Thermophilus: Characterization of the Sulfhydryl State by Protein‐Film Voltammetry,” Biochemistry (US), 41 (2002) 14054‐14065

  30. Y. Zu, S. D. Bernardo, T. Yagi, J. Hirst, “Redox Properties of the [2Fe‐2S] Center in the 24kDa (NQO2) Subunit of NADH:Ubiquinone Oxidoreductase (Complex I),” Biochemistry (US), 41 (2002) 10056‐10069

  31. Y. Zu, J. A. Fee, J. Hirst, “Complete Thermodynamic Characterization of Reduction and Protonation of the bc1‐type Rieske [2Fe‐2S] Center of Thermus Thermophilus,” J. Am. Chem. Soc., 123 (2001) 9906‐9907

  32. F. Kanoufi, C. Cannes, Y. Zu, A. J. Bard, “Scanning Electrochemical Microscopy. 43. Investigation of Oxalate Oxidation and Electrogenerated Chemiluminescence Across the Liquid‐Liquid Interface,” J. Phys. Chem. B, 105 (2001) 8951‐8962

  33. Y. Zu and A. J. Bard, “Electrogenerated hemiluminescence. 67. Dependence of Light Emission of the Tris(2,2') bipyridylruthenium(II)/Tripropylamine System on Electrode Surface Hydrophobicity,” Anal. Chem., 73 (2001) 3960‐3964

  34. Y. Zu, Z. F. Ding, J. Zhou, Y. Lee, A. J. Bard, “Scanning Optical Microscopy with an Electrogenerated Chemiluminescent Light Source at a Nanometer Tip,” Anal. Chem., 73 (2001) 2153‐2156

  35. F. Kanoufi, Y. Zu, A. J. Bard, “Homogeneous Oxidation of Trialkylamines by Metal Complexes and its Impact on Electrogenerated Chemiluminescence in the Trialkylamine/Ru(bpy)32+ System,” J. Phys. Chem. B, 105 (2001) 210‐216

  36. Y. Zu and A. J. Bard, “Electrogenerated Chemiluminescence. 66. The Role of Direct Coreactant Oxidation in the Ruthenium Tris(2,2')bipyridyl/Tripropylamine System and the Effect of Halide Ions on the Emission Intensity,” Anal. Chem., 72 (2000) 3223‐3232

  37. J. Zhou, Y. Zu, A. J. Bard, “Scanning Electrochemical Microscopy. Part 39. The Proton/Hydrogen Mediator System and Its Application to the Study of the Electrocatalysis of Hydrogen Oxidation,” J. Electroanal. Chem., 491 (2000) 22‐29

  38. Y. Zu, F. R. F. Fan, A. J. Bard, “Inverted Region Electron Transfer Demonstrated by Electrogenerated Chemiluminescence at the Liquid/Liquid Interface,” J. Phys. Chem. B, 103 (1999) 6272‐6276

  39. S. K. Lee, Y. Zu, A. Herrmann, Y. Geerts, K. Mullen, A. J. Bard, “Electrochemistry, Spectroscopy and Electrogenerated Chemiluminescence of Perylene, Terrylene, and Quaterrylene Diimides in Aprotic Solution,” J. Am. Chem. Soc., 121 (1999) 3513‐3520

  40. C. S. Cha and Y. Zu, “Behavior of Perfluorinated Surfactants at the Electrode/Solution Interface,” Langmuir, 14 (1998) 6280‐6286

  41. B. Ren, F. M. Liu, J. Xie, B. W. Mao, Y. Zu, Z. Q. Tian, “In Situ Monitoring of Raman Scattering and Photoluminescence from Silicon Surfaces in HF Aqueous Solutions,” Appl. Phys. Lett., 72 (1998) 933‐935

  42. Y. Zu, L. Xie, B. W. Mao, Z. W. Tian, “Study on Silicon Etching using the Confined Etchant Layer Technique,” Electrochim. Acta, 43 (1998) 1683‐1690

  43. Y. Zu, P. F. Liu, C. S. Cha, X. Li, “Investigation of the interaction Between Nafion and Several Trisbipyridyl Complexes by Spectroscopic Method,” Chinese Chemical Letters, 8[4] (1997) 357‐359

  44. Y. Zu, L. Xie, Z. W. Tian, Z. X. Xie, J. Q. Mu, B. W. Mao, “Improvement of Silicon Etching Resolution using the Confined Etchant Layer Technique,” Chinese Science Bulletin, 42[15] (1997) 1318‐1319

  45. Y. Zu and C. S. Cha, “Study on the Hydrophicility of Nafion Membrane Surface,” Electrochemistry (in Chinese), 3[1] (1997), 45‐49

  46. C. S. Cha and Y. Zu, “The Behavior of Perfluorinated Surfactants at Platinum Electrode,” Russ. J. Electrochem., 31[8] (1995) 796‐801

  47. Y. Zu and J. W. Yan, “Effects of Perfluorinated Surfactants on Electrochemical Reactions,” Material Protection (in Chinese), 12 (1997) 8‐11

  48. Y. Zu, L. Xie, Z. W. Tian, “Factors Limiting the Resolution of Electrochemical Etching,” Acta Physico‐Chimica Sinica (in Chinese), 13[11] (1997) 965‐968

  49. Y. Zu and C. S. Cha, “Improvement of Hydtophilicity of Nafion Membrane Surface by Modification with Perfluorinated Sutfactants,” Chinese J. Appl. Chem. (in Chinese), 12[2] (1995) 33‐36

  50. Y. Zu and Q. H. Dong, “Mechanism of Li‐CuO Battery: 3. Effect of Discharging Current,” J. Wuhan Univ. (in Chinese), 41[2] (1995) 185‐189

  51. Y. Zu and Q. H. Dong, “Mechanism of Li‐CuO Battery: 2. A Capacitance Study,” Chem. J. Chinese Univ. (in Chinese), 39[5] (1993) 66‐69

  52. Y. Zu and Q. H. Dong, “Mechanism of Li‐CuO Battery: 1. A Photoelectrochemical Study,” J. Wuhan Univ. (in Chinese), 14 (1993) 1261‐1264