Yuwei HU

Research Scientist

Tel: +65 6319 4807

Email: ywhu@imre.a-star.edu.sg

Research Scientist, NanoBio Lab, Singapore, 2018‐present

Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, 2018

Research Fellow, National University of Singapore, 2016‐2017

Post‐Doctoral Researcher, The Hebrew University of Jerusalem, 2013‐ 2016

Ph.D. in Analytical Chemistry, Jilin University, China, 2013

M.Sc. in Analytical Chemistry, Qingdao University of Science & Technology, China, 2010

B.Sc. in Chemistry, Qingdao University of Science & Technology, China, 2007


  1. Y. Hu and J. Y. Ying, “A Strong Acid-Induced DNA Hydrogel Based on pH-Reconfigurable A-Motif Duplex,” Small, DOI: 10.1002/smll.202205909.

  2. Y. Hu and J. Y. Ying, “Reconfigurable A-Motif, i-Motif and Triplex Nucleic Acids for Smart pH-Responsive DNA Hydrogels,” Mater. Today, DOI: 10.1016/j.mattod.2022.12.003.

  3. Y. Hu, S. Gao, H. Lu, J.-Y. Ying, “Acid-Resistant and Physiological pH-Responsive DNA Hydrogel Composed of A-Motif and i-Motif toward Oral Insulin Delivery”, J. Am. Chem. Soc. 2022, 144, 5461−5470

  4. B. Xu, X. Han, Y. Hu, Y. Luo, C.-H. Chen, Z. Chen, P. Shi, “A Remotely Controlled Transformable Soft Robot Based on Engineered Cardiac Tissue Construct”, Small, 2019, 1900006

  5. S. Guo, W. N. Lin, Y. Hu, G. Sun, D.-T. Phan, C.-H. Chen, “Ultrahigh-throughput droplet microfluidic device for single-cell miRNA detection with isothermal amplification”, Lab Chip, 2018, 18, 1914–1920

  6. Y. Hu, A. Cecconello, A. Idili, F. Ricci, I. Willner, “Triplex DNA Nanostructures: From Basic Properties to Applications,” Angew. Chem. Int. Ed., 56 (2017) 15210‐15233

  7. J. S. Kahn, Y. Hu, I. Willner, “Stimuli‐Responsive DNA‐Based Hydrogels: From Basic Principles to Applications,” Acc. Chem. Res., 50 (2017) 680‐690

  8. Y. Hu, J. S. Kahn, W. Guo, F. Huang, M. Fadeev, D. Harries, I. Willner, “Reversible Modulation of DNA‐Based Hydrogel Shapes by Internal Stress Interactions,” J. Am. Chem. Soc., 138 (2016) 16112‐16119

  9. Y. Hu, J. Ren, C.‐H. Lu, I. Willner, “Programmed pH‐Driven Reversible Association and Dissociation of Inter‐Connected Circular DNA Dimer Nanostructures,” Nano Lett., 16 (2016) 4590‐4594

  10. Y. Hu, W. Guo, J. S. Kahn, M. A. Aleman‐Garcia, I. Willner, “A Shape Memory DNA‐Based Hydrogel Exhibiting Two Internal Memories,” Angew. Chem. Int. Ed., 55 (2016) 4210‐4214

  11. X. Yu, Y. Hu, J. S. Kahn, A. Cecconello, I. Willner, “Orthogonal Dual Triggered Shape‐Memory DNABased Hydrogels,” Chem.‐Eur. J., 22 (2016) 14504‐14507

  12. M. A. Aleman Garcia, Y. Hu, I. Willner, “Switchable Supramolecular Catalysis using DNA‐templated Scaffolds,” Chem. Commun., 52 (2016) 2153‐2156

  13. Y. Hu, C.‐H. Lu, W. Guo, M. A. Aleman‐Garcia, J. Ren, I. Willner, “A Shape‐Memory Acrylamide/DNA Hydrogel Exhibiting Switchable Dual pH Responsiveness,” Adv. Funct. Mater., 25 (2015) 6867‐6874

  14. J. Ren, Y. Hu, C.‐H. Lu, W. Guo, F. Ricci, I. Willner, “pH Responsive and Switchable Triplex‐Based DNA Hydrogels,” Chem. Sci., 6 (2015) 4190‐4195

  15. C.‐H. Lu, W. Guo, Y. Hu, X.‐J. Qi, I. Willner, “Multi‐Triggered Shape‐Memory Acrylamide–DNA Hydrogels,” J. Am. Chem. Soc., 137 (2015) 15723‐15731

  16. Y. Hu, F. Wang, C.‐H. Lu, J. Girsh, E. Golub, I. Willner, “Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures,” Chem.‐Eur. J., 20 (2014) 16203‐16209

  17. W. Zhang, F. Li, Y. Hu, S. Gan, D. Han, Q. Zhang, L. Niu, “Perylene Derivative‐Bridged Au–Graphene Nanohybrid for Label‐Free HpDNA Biosensor,” J. Mater. Chem. B, 2 (2014) 3142‐3148

  18. N. Zhang, X. Lv, W. Ma, Y. Hu, F. Li, D. Han, L. Niu, “Direct Electron Transfer of Cytochrome C at Mono‐dispersed and Negatively Charged Perylene–Graphene Matrix,” Talanta, 107 (2013) 195‐202

  19. Y. Hu, T. Yang, Q. Li, Q. Guan, K. Jiao, “Conjugated Self‐Doped Polyaniline–DNA Hybrid as Trigger for Highly Sensitive Reagentless and Electrochemical Self‐Signal Amplifying DNA Hybridization Sensing,” Analyst, 138 (2013) 1067‐1074

  20. Y. Hu, F. Li, D. Han, T. Wu, Q. Zhang, L. Niu, Y. Bao, “Simple and Label‐Free Electrochemical Assay for Signal‐On DNA Hybridization Directly at Undecorated Graphene Oxide,” Anal. Chim. Acta, 753 (2012) 82‐89

  21. L. Fan, Y. Hu, X. Wang, L. Zhang, F. Li, D. Han, Z. Li, Q. Zhang, Z. Wang, L. Niu, “Fluorescence Resonance Energy Transfer Quenching at the Surface of Graphene Quantum Dots for Ultrasensitive Detection of TNT, Talanta, 101 (2012) 192‐197

  22. Y. Hu, K. Wang, Q. Zhang, F. Li, T. Wu, L. Niu, “Decorated Graphene Sheets for Label‐Free DNA Impedance Biosensing,” Biomaterials, 33 (2012) 1097‐1106

  23. Y. Hu, D. Han, Q. Zhang, T. Wu, F. Li, L. Niu, “Perylene Ligand Wrapping G‐Quadruplex DNA for Label‐Free Fluorescence Potassium Recognition,” Biosen. Bioelectron., 38 (2012) 396‐401

  24. Y. Hu, F. Li, X. Bai, D. Li, S. Hua, K. Wang, L. Niu, “Label‐Free Electrochemical Impedance Sensing of DNA Hybridization Based on Functionalized Graphene Sheets,” Chem. Commun., 47 (2011) 1743‐1745

  25. Y. Hu, S. Hua, F. Li, Y. Jiang, X. Bai, D. Li, L. Niu, “Green Synthesized Gold Nanoparticles Decorated Graphene Sheets for Label‐Free Electrochemical Impedance DNA Hybridization Biosensing,” Biosen. Bioelectron., 26 (2011) 4355‐4361

  26. J. Chai, F. Li, Y. Hu, Q. Zhang, D. Han, L. Niu, “Hollow Flower‐Like AuPd Alloy Nanoparticles: One Step Synthesis, Self‐Assembly on Ionic Liquid‐functionalized Graphene and Electrooxidation of Formic Acid,” J. Mater. Chem., 21 (2011) 7922‐17929

  27. T. Yang, Y. Hu, W. Li, K. Jiao, “Single Stranded DNA‐Guided Electropolymerization of Polythionine Nanostrip to the Sensing of H2O2,” Colloid. Surface. B, 83 (2011) 179‐182

  28. Y. Hu, T. Yang, X. Wang, K. Jiao, “Highly Sensitive Indicator‐Free Impedance Sensing of DNA Hybridization Based on Poly(m‐aminobenzenesulfonic acid)/TiO2 Nanosheet Membranes with Pulse Potentiostatic Method Preparation,” Chem.‐ Eur. J., 16 (2010) 1992‐1999

  29. X. Zhang, K. Jiao, S. Liu, Y. Hu, “Readily Reusable Electrochemical DNA Hybridization Biosensor Based on the Interaction of DNA with Single‐Walled Carbon Nanotubes,” Anal. Chem., 81 (2009) 6006‐6012

  30. X. Zhang, S. Liu, K. Jiao, Y. Hu, “Fabrication, Characterization, and Application of Sandwich‐Type Electrode Based on Single‐Walled Carbon Nanotubes and Room Temperature Ionic Liquid,” Electroanal., 20 (2008) 1909‐1916